A picture of Manuela Ayee-Leong

Dr. Manuela Ayee-Leong

Associate Professor of Chemistry and Engineering



Dr. Ayee has experience in both academia and industry. Her research interests combine computational and experimental techniques to elucidate the molecular mechanisms underlying the effects of small molecules and proteins on membrane biomechanics and cell biophysical properties, with a focus on pathogenesis. Some applications include:

  • Examining the molecular interactions of myelin protein zero to uncover the pathophysiological mechanisms that drive Charcot-Marie-Tooth peripheral neuropathy disease.
  • Investigating the modulation of cellular and tissue biomechanics by oxidized lipids and sterols under hypercholesterolemic conditions.
  • Elucidating the roles played by toxins in modulating the properties of lipid layers.