A picture of Manuela Ayee-Leong

Dr. Manuela Ayee-Leong

Associate Professor of Chemistry and Engineering



Dr. Ayee-Leong has experience in both academia and industry. Her research interests combine computational & experimental techniques to elucidate the molecular mechanisms underlying effects of small molecules & proteins on membrane biomechanics & cell biophysical properties, with a focus on pathogenesis. Some applications include:

  • Examining molecular interactions of myelin protein zero to uncover pathophysiological mechanisms that drive Charcot-Marie-Tooth peripheral neuropathy disease
  • Investigating modulation of cellular & tissue biomechanics by oxidized lipids & sterols under hypercholesterolemic conditions
  • Elucidating roles played by toxins in modulating properties of lipid layers